The Bombers will don the yellow armbands on Saturday night for their annual Tackling Childhood Cancer game. (Photo: AFL Photos)

Essendon's round 15 clash with Melbourne will mark its fifth annual Tackling Childhood Cancer game in support of long-standing charity partner Challenge.

The Bombers will proudly wear the Challenge logo on the front of their guernsey which also features the yellow armband, inspired by former premiership player and cancer survivor Adam Ramanauskas.

Challenge has been Essendon’s charity partner for over 20 years. A not-for-profit organisation, it provides daily support for children and families living with cancer or a life-threatening blood disorder from the time of diagnosis, through treatment and beyond.

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The Bombers have committed one game each season since 2017 to Challenge.

In a non-COVID world, the game would normally see 22 Challenge kids run out on to the ground, hand-in-hand with their AFL superheroes.

Zach Merrett runs out with a couple of Challenge kids for the Bombers' 2019 Tackling Childhood Cancer game. (Photo: AFL Photos)

Saturday night's edition will still involve a pre-game interaction between the players and kids, be it virtually or in person.

The club would like to acknowledge its longest-serving partner Yakult, which has already made a $10k donation to Challenge. To support Challenge and kids living with cancer, donate here or text 'CHALLENGE' to 0476 000 111.