Essendon's players and match-day staff will depart for Perth on Wednesday morning following a change to their travel plans due to Victoria's COVID outbreak.

Originally scheduled to fly out on Friday morning for Saturday night's clash with West Coast, the Bombers' travelling party will arrive in Perth this afternoon.

Under government guidelines, they'll be tested upon arrival and isolate until they receive negative results ahead of the game.

The Bombers are set to face the Eagles from 7:40pm AEST at Optus Stadium on Saturday night.