Essendon has named five changes for its round 12 clash with St Kilda at the Gabba on Sunday, welcoming back star defender Michael Hurley.

Hurley returns to the line-up after being managed against the Suns, while Jacob Townsend has also been recalled after missing the draw with concussion.

Third-gamer Sam Draper is another inclusion, while youngsters Josh Begley and Kobe Mutch will play their first games of the season.

THE ULTIMATE PREVIEW: SAINTS v BOMBERS

Given the Bombers' four-day break between rounds 11 and 12 and third game in 10 days, Devon Smith, Mason Redman, Aaron Francis and Tom Bellchambers will be managed but expected to be available for selection against Richmond next week. 

David Zaharakis also exits the side after suffering a season-ending quad injury.

(Watch senior coach John Worsfold discuss the changes below)

03:37

Fan favourite Anthony McDonald-Tipungwuti will play his 100th game on Sunday, becoming just the second player after his idol Dean Rioli to get his name on the No.43 locker.

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ESSENDON'S ROUND 12 TEAM:

Backs: Adam Saad, Michael Hurley, Brandon Zerk-Thatcher
Half-backs: Jordan Ridley, Martin Gleeson, Matt Guelfi
Centre: Tom Cutler, Andrew McGrath, Darcy Parish
Half-forwards: Conor McKenna, James Stewart, Anthony McDonald-Tipungwuti
Forwards: Josh Begley, Shaun McKernan, Will Snelling
Followers: Sam Draper, Dylan Shiel, Zach Merrett
Interchange: Kyle Langford, Jacob Townsend, Kobe Mutch, Dylan Clarke
Emergencies: Tom Bellchambers, Mitch Hibberd, Mason Redman, Brayden Ham

In: Hurley, Townsend, Draper, Mutch, Begley

Out: Smith (managed), Bellchambers (managed), Francis (managed), Redman (managed), Zaharakis (quad)

Milestone: Anthony McDonald-Tipungwuti - 100 AFL games