O’Brien has been selected for just his third game of his career after being included in the final 22 to face the Dogs.
The 20 year old has had a consistent season at VFL level in recent weeks taking on a defensive role in the midfield as well as across half forward.
He made a dream start to his career in his debut against Richmond in Round 22 last season kicking a goal with his first kick in AFL football.
The club will name its captain on game day.
See the final 22 below.
B: Dempsey, Fletcher, Pears
HB: Baguley, Hooker, Hibberd
C: Goddard, Heppell, Melksham
HF: Myers, Hurley, Stanton
F: Merrett, Carlisle, Kommer
R: Ryder, Zaharakis, Winderlich
Int: Howlett, Colyer, Bellchambers, O’Brien
In: O’Brien
Out: Watson (collarbone)
