Darcy Parish will miss this week's match against GWS after injuring his calf at training.
The number five pick from the 2015 National Draft was one of three changes made to the side with James Kelly (groin) and Matt Dea also left out.
“Darcy suffered a calf strain during our main training session on Wednesday,” High Performance Manager Justin Crow said.
“We’ll assess the injury over the coming days before determining just how long he’ll be sidelined."
Midway through his second AFL season, Parish has played 30 senior games and has averaged 21 disposals per match.
Kelly is suffering from groin tightness and the Club opted not to risk the 302 game veteran this weekend.
Patrick Ambrose wasn’t considered for selection after failing to get through his final training session.
The defender has missed the last five games with a quad injury.
“Paddy just tightened up while kicking during that final session on Wednesday, so he’ll need to complete some further rehabilitation,” Crow said.
“Like Darcy, we’ll assess Paddy over the next few days to establish a timeframe to work towards.”
The Bombers play the Giants on Saturday and then host Port Adelaide next week before their mid-season bye.