The 28-year-old was helped from the ground during the second quarter of the NAB Cup clash after rolling his ankle in the centre square.
While he'll undergo scans on Saturday to assess the injury closer, the Bombers believe the complaint is not serious.
"We were having a discussion at half time about whether he would come back onto the ground in the second half, so hopefully that's a sign it's not too severe," coach Matthew Knights said, after the game.
"It was a blow because he was playing well and we would have liked to have got the whole game into him, match conditioning perspective."
Knights was pleased to see Scott Lucas, Alwyn Davey, Jason Winderlich and David Myers all get through their first match for the year after returning from long-term injuries.
"We expected that match conditioning would give way because it was their first game up after long stints on the sidelines, so it was going to be very fresh for them," he said.
"They probably did get a bit weary as the night went on but there was no excuse for the other 22 guys in the team.
"Those guys you can excuse a bit tonight."
He was particularly chuffed to see Winderlich get amongst it to collect the most possessions for the Essendon side, considering the midfielder's career was on the line last year owing to a persistent back injury.
"I felt he is a very important player for us because he does get through the lines hard and his kicking usually hits the target," he said.
"I thought he played quite well, and for Alwyn, coming off a knee reconstruction, when you go to push off and change directions, you're going to take a few weeks to get your confidence with that.
"We're going to have to give him some slack for a few games but it was great to see him play some minutes."
Knights couldn't explain the "brain fade" Davey experienced in the dying stages of the game, when he gave Lion Jack Redden a potentially game-saving shot on goal after gifting him a silly 50m penalty for incorrectly returning the ball.
"I asked him after the game if he had a fishing trip up at Cairns organised, because that's where we were going if that goal had gone through," he said.
"He didn't see the comical side of that.
"I don't know what went through his mind. It might have been a bit of fatigue."
