ESSENDON has marked its historic first AFLW fixture at Windy Hill with a 12-point win over St Kilda, continuing its unbeaten start to the season.

Prolific midfielder Maddy Prespakis starred again with a game-high 29 disposals in the Bombers' 6.4 (40) to 4.4 (28) victory on Sunday.

It was Essendon's first game at its spiritual home in a national competition - either men's or women's - since August 1991.

Prespakis continued her hot form, winning 15 contested possessions and five clearances to lead her side to victory.

Georgia Gee (19 touches, one goal), co-captain Bonnie Toogood (17, one), Sophie Alexander (19 disposals) and Brooke Walker (15, six clearances) were also strong contributors the Bombers.

"There hasn't been a game of footy here for so many years and for us to create our own history and get our first win here is incredible," childhood Bombers fan Prespakis told the Seven Network after the game.

"I love the Essendon footy club and this is our home and this is our journey, so I'm really proud to be a part of it."

The Bombers' win came at a cost, with co-captain Steph Cain undergoing a concussion test during the final quarter after her head met the turf in a dump tackle from Jaimee Lambert.

Essendon was dominant early and grabbed the ascendancy with three straight goals in the opening 10 minutes.

The Saints gradually dragged their way back into the contest, kicking four of the next five majors to level the scores midway through the third quarter.

But the Bombers steadied late in the third term and turned for home 12 points in front.

Neither side managed to score in a hard-fought final period, marking a second win in a row to kick off the Bombers’ campaign.

ESSENDON        3.1     3.3     6.4    6.4  (40)
ST KILDA           1.2    2.4     4.4    4.4  (28)

GOALS:
Vogt, Clarke, Gee, Toogood, Wuetschner, Radford

BEST:
Prespakis, Toogood, Gee, Walker, Alexander, Vogt

Crowd: 3,915 at Windy Hill