Football great Neale Daniher's fight against motor neurone disease (MND) has inspired many and now he has been recognised for his efforts with a prestigious award.

Daniher was named Melburnian of the Year in a ceremony at the Melbourne Town Hall on Saturday night, with the former player and coach pledging to keep battling the "beast". 

Lord Mayor Robert Doyle said Daniher's ability to connect with others was a major factor in him receiving the sought-after award. 

"It is the way he has galvanised the community to get behind a crucial cause," Doyle said.

Daniher has spearheaded the annual Big Freeze at the 'G, which has quickly become an iconic event on Queen's Birthday, while the Daniher's Drive road trip has similarly met with massive support to raise funds to combat MND.

The inspirational 55-year-old has raised almost $12 million for the Cure For MND charity.

Daniher will soon enter another life-altering phase in his fight against the disease, the former Melbourne coach having his house prepared for when he is no longer able to walk. 

"I'll eventually become wheelchair-bound, eventually I’ll have to be lifted by hoist, all this within a two-to-three year timespan," Daniher told the Herald Sun.

"It’s very costly, it’s not an easy life, neither for the sufferer nor for the people who need to look after you."