Matt Guelfi will make his return from a calf strain this Saturday as Essendon VFL faces Collingwood at Victoria Park.

Guelfi headlines three inclusions for the VFL Dons, who'll also regain midfielders Elijah Tsatas and Bailey Scott for the Anzac Round clash.

Sam Weideman is set to support Lewis Hayes in defence again after a strong outing last week, while Cam Nyko holds his spot after a promising debut against Southport.

Ricky Monti, Jake Moorhead and Alex Molan are the three who'll make way this week.

The Bombers take on the Pies from 2:05pm AEST at Victoria Park, with an Anzac observance and minute's silence to take place before the first bounce.

Essendon VFL round five team v Collingwood

B J. Eckersley (58) W. Hoare (51) L. Hayes (18)
HB L. Lual (34) S. Weideman (10) X. O'Neill (55) (C)
C J. Hately (50) E. Tsatas (5) A. Roberts (38)
HF T. Wanganeen (40) N. Caddy (30) M. Guelfi (35)
F J. Davey (36) V. Visentini (39) C. Gray (81)
R N. Bryan (24) D. Shiel (9) B. Scott (77)
INT S. McKay (80) M. Foley (73) J. Peris (53)
  T. Toma (61) C. Nyko (62)  
23rd Player C. Nyko (62)
EMG R. Monti (52) J. Jedwab (68) A. Molan (82)
  J. Moorhead (75)  

Ins: B. Scott, E. Tsatas, M. Guelfi

Outs: R. Monti (omit), J. Moorhead (omit), A. Molan (omit)